GEN-ERIC News

MIT scientists propose that blood may help us think, in addition to its well-known role as the conveyor of fuel and oxygen to brain cells. “We hypothesize that blood actively modulates how neurons process information,” Christopher Moore, a principal investigator in the McGovern Institute for Brain Research at MIT, explained in an invited review in the October issue of the Journal of Neurophysiology. “Many lines of evidence suggest that blood does something more interesting than just delivering supplies. If it does modulate how neurons relay signals, that changes how we think the brain works.” According to Moore’s Hemo-Neural Hypothesis, blood is not just a physiological support system but actually helps control brain activity. Specifically, localized changes in blood flow affect the activity of nearby neurons, changing how they transmit signals to each other and hence regulating information flow throughout the brain. Ongoing studies in Moore’s laboratory support this view, showing that blood flow does modulate individual neurons. Moore’s theory has implications for understanding brain diseases such as Alzheimer’s, schizophrenia, multiple sclerosis and epilepsy.